Soluble and matrix‐associated heparan sulfate proteoglycans increase expression of erb‐B2 and erb‐B3 in colon cancer cell lines
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منابع مشابه
Catabolism of heparan sulfate proteoglycans in Drosophila cell lines.
We have studied intracellular catabolism of heparan sulfate proteoglycans (HSPGs) in Drosophila cell lines, Kc and S2, by a series of pulse-chase experiments using [(35)S]sulfate as a precursor in metabolic labeling experiments. HSPGs in culture medium and cell layer were separately purified by serial chromatographic procedures using Q-Sepharose and Superose 6 for characterization. Analysis of ...
متن کاملRole of heparan sulfate proteoglycans in cell signaling and cancer.
The correct growth and development of multicellular organisms depends on the reception of numerous extracellular signals that activate various signal transduction cascades within the target cells. The activity of these pathways, such as the receptor tyrosine kinases (RTKs), transforming growth factor-β (TGF-β), Wnts, and Hedgehogs (Hh), are usually regulated by the binding of extracellular liga...
متن کاملAlterations of Heparan Sulfate Proteoglycans in Cancer
Heparan sulfate proteoglycans (HSPGs) are glycoproteins, with the common characteristic of containing covalently attached heparan sulfate glycosaminoglycan chains (GAGs). These molecules are highly modified in cancer, contributing to tumorigenesis. In fact, the expression of HSPGs is markedly altered during malignant transformation and tumor progression, affecting both the PG core proteins and ...
متن کاملHeparan sulfate proteoglycans.
Heparan sulfate proteoglycans are found at the cell surface and in the extracellular matrix, where they interact with a plethora of ligands. Over the last decade, new insights have emerged regarding the mechanism and biological significance of these interactions. Here, we discuss changing views on the specificity of protein-heparan sulfate binding and the activity of HSPGs as receptors and core...
متن کاملHeparan sulfate proteoglycans
Studies of the involvement of ECM molecules in cell attachment, growth, and differentiation have revealed a central role of heparan sulfate (HS) proteoglycans (HSPGs) in early embryogenesis, morphogenesis, angiogenesis, and epithelial-mesenchymal interactions (1–3). HS chains bind a multitude of proteins and ensure that a wide variety of bioactive molecules (e.g., heparin-binding growth factors...
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ژورنال
عنوان ژورنال: International Journal of Cancer
سال: 2001
ISSN: 0020-7136,1097-0215
DOI: 10.1002/1097-0215(200002)9999:9999<::aid-ijc1045>3.0.co;2-o